Artichoke Spinach Grilled Cheese

Featured in: Simple Plates & Pairings

This artichoke spinach grilled cheese combines the beloved flavors of spinach-artichoke dip with a classic sandwich. Creamy cheeses and fresh vegetables are spread between golden sourdough slices and pan-fried until perfectly melted and crispy. It's comfort food at its finest, ready in just 25 minutes.

Updated on Tue, 20 Jan 2026 12:09:00 GMT
Golden, crisp sourdough grilled cheese sandwich filled with creamy spinach-artichoke dip, oozing melted cheeses and served warm.  Save
Golden, crisp sourdough grilled cheese sandwich filled with creamy spinach-artichoke dip, oozing melted cheeses and served warm. | ladledrift.com

The rain was coming down sideways last Tuesday when I decided to turn spinach artichoke dip into an actual sandwich. My roommate walked through the door and stopped dead in her tracks, asking what smelled like a restaurant in our tiny apartment. That first bite—crunchy sourdough giving way to this impossibly creamy, cheesy center—silenced both of us completely.

I made these again when my sister came over after a terrible day at work. She took one bite, closed her eyes, and said this sandwich fixed something she didnt know was broken. Now she texts me whenever she spots artichokes on sale at the grocery store.

Ingredients

  • Fresh spinach: The bright green color keeps the filling from looking too heavy
  • Artichoke hearts: Jarred ones work perfectly, just give them a good chop
  • Cream cheese: Softened to room temperature makes mixing effortless
  • Mozzarella and Monterey Jack: This blend melts into the perfect stretchy consistency
  • Parmesan: Adds a salty sharpness that cuts through all the richness
  • Sourdough bread: The sturdy texture holds up to the generous filling
  • Garlic: One small clove goes a long way here
  • Red pepper flakes: Optional but adds a lovely warmth

Instructions

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Make the filling:
Toss everything except the bread and butter into a bowl, mashing and stirring until the spinach is evenly distributed throughout all that cheese.
Assemble the sandwiches:
Pile a generous amount of filling onto four slices, then top with the remaining bread slices.
Butter the bread:
Spread softened butter on the outside of each sandwich—this is what creates that golden crust everyone fights over.
Grill to perfection:
Cook in a hot skillet for about 4 minutes per side, pressing gently with your spatula, until the bread turns deep golden brown and cheese starts escaping at the edges.
Let them rest:
Wait just one full minute before slicing so the filling has time to set up slightly.
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A thick Artichoke Spinach Grilled Cheese on buttery sourdough, revealing a vibrant green filling of spinach and tender artichokes.  Save
A thick Artichoke Spinach Grilled Cheese on buttery sourdough, revealing a vibrant green filling of spinach and tender artichokes. | ladledrift.com

My dad tried these and immediately asked why nobody had thought of this combination before dinner. Now he requests them whenever he visits, claiming they are better than any restaurant version he has ever tried.

Make It Your Own

Sometimes I throw in chopped sun-dried tomatoes when I want extra tang. A handful of fresh basil leaves added right before serving brightens everything up and makes the sandwich feel fancier than it really is.

What to Serve Alongside

A simple tomato soup turns this into the ultimate comfort meal. When I am feeling lighter, a crisp green salad with lemon vinaigrette cuts through all that rich cheese beautifully.

Make Ahead Strategy

The filling keeps perfectly in the refrigerator for two days, which means you can prep everything on Sunday and have restaurant-quality sandwiches ready to cook in minutes on busy weeknights.

  • Toast the bread slightly before assembling if you prefer extra crunch
  • A panini press works wonderfully if you have one
  • Leftovers reheat surprisingly well in the oven
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Close-up of Artichoke Spinach Grilled Cheese, showing melted mozzarella and Monterey Jack stretching from golden bread slices. Save
Close-up of Artichoke Spinach Grilled Cheese, showing melted mozzarella and Monterey Jack stretching from golden bread slices. | ladledrift.com

These sandwiches have become my go-to for nights when I need comfort food but still want something that feels special. Hope they become a favorite in your kitchen too.

Recipe FAQs

Can I prepare the filling ahead of time?

Yes, the filling can be prepared up to 2 days in advance and stored in the refrigerator. Simply assemble and cook the sandwiches when ready to serve.

What bread alternatives work well for this sandwich?

Whole wheat bread adds nutritional fiber, while gluten-free bread accommodates dietary restrictions. Any sturdy bread that can hold the creamy filling without falling apart works well.

How can I customize the filling?

Add sun-dried tomatoes or chopped scallions for extra flavor and texture. You can also adjust the cheese blend based on your preferences or what's available.

What's the best way to achieve golden, crispy bread?

Lightly butter both sides of the sandwich and cook over medium heat for 3-4 minutes per side. Press gently during cooking to ensure even contact with the skillet and proper cheese melting.

What sides pair well with this sandwich?

A simple tomato soup complements the creamy sandwich beautifully, as does a fresh green salad for a lighter balance to the rich, cheesy filling.

Artichoke Spinach Grilled Cheese

Decadent grilled cheese sandwich featuring creamy spinach-artichoke dip filling and melted cheese between crispy sourdough.

Prep time
15 minutes
Cook time
10 minutes
Time needed
25 minutes
Created by Zoey Sullivan


Skill level Easy

Cuisine American

Makes 4 Portions

Diet info Meat-free

What You Need

Vegetables

01 1 cup fresh spinach, chopped (or 1/2 cup frozen, thawed and drained)
02 1 cup canned or jarred artichoke hearts, drained and chopped

Dairy

01 4 oz cream cheese, softened
02 1/2 cup shredded mozzarella cheese
03 1/2 cup shredded Monterey Jack or Swiss cheese
04 1/4 cup grated Parmesan cheese
05 2 tablespoons unsalted butter, softened

Bread

01 8 slices sourdough bread

Seasonings

01 1 small garlic clove, minced
02 1/4 teaspoon black pepper
03 1/8 teaspoon crushed red pepper flakes (optional)
04 Pinch of salt

How-To

Step 01

Prepare the filling: In a mixing bowl, combine cream cheese, mozzarella, Monterey Jack or Swiss, Parmesan, spinach, artichokes, garlic, black pepper, red pepper flakes, and salt. Mix until well blended.

Step 02

Assemble sandwiches: Lay out sourdough slices. Spread artichoke-spinach mixture evenly onto 4 slices. Top with remaining bread slices to form sandwiches.

Step 03

Butter the exterior: Lightly butter the outside of each sandwich on both sides.

Step 04

Cook until golden: Heat a large skillet or griddle over medium heat. Place sandwiches in the pan and cook 3 to 4 minutes per side, pressing gently, until bread is golden brown and cheese is melted.

Step 05

Rest and serve: Remove from skillet, let rest 1 minute, then slice and serve warm.

Tools needed

  • Mixing bowl
  • Spoon or spatula
  • Knife and cutting board
  • Skillet or griddle
  • Spatula for flipping

Allergy notice

Double-check your ingredients for allergens, and ask a healthcare expert if you’re not sure.
  • Contains dairy (cheese, butter)
  • Contains wheat (bread)
  • May contain soy depending on bread and cheese brands
  • Check labels for potential cross-contamination if allergies are severe

Nutrition info (per portion)

This nutrition guide is for general info—always consult a medical pro for advice.
  • Calorie count: 410
  • Fat content: 23 grams
  • Carbohydrates: 38 grams
  • Proteins: 15 grams