Italian Sub Grilled Cheese

Featured in: One-Pot & One-Dish Meals

This Italian Sub Grilled Cheese brings together classic Italian flavors in a warm, melted sandwich experience. Layer Italian bread with softened butter, provolone cheese, salami, and pepperoni, then top with a zesty lettuce mixture made from iceberg lettuce, mayo, red wine vinegar, and oregano. Grill until the bread turns golden and the cheese melts into creamy perfection, approximately 3-4 minutes per side. The result is a satisfying, restaurant-quality sandwich ready in just 20 minutes total.

Updated on Tue, 20 Jan 2026 13:19:00 GMT
Golden-brown Italian Sub Grilled Cheese sandwich with melted provolone, salami, and pepperoni stacked on buttery bread. Save
Golden-brown Italian Sub Grilled Cheese sandwich with melted provolone, salami, and pepperoni stacked on buttery bread. | ladledrift.com

The rain was coming down sideways last Tuesday when I desperately needed something that felt like a hug in sandwich form. I'd been staring at the deli meat in my fridge for days, wondering how to make it sing. Then it hit me why not transform those cold cuts into the grilled cheese of my dreams? The sizzle of butter in a pan suddenly sounded like the best possible plan.

My roommate walked in mid sizzle and literally stood behind me breathing in the buttery salami perfumed air. She claimed she was just checking the mail but I caught her lingering at the kitchen island for a solid ten minutes. We ended up splitting one sandwich right there standing up because neither of us could wait for proper plates. Sometimes the best meals happen on your feet.

Ingredients

  • Italian bread: Sturdy enough to hold all those toppings without getting soggy but still with that nice chewy crust
  • Unsalted butter: Softened to room temperature so it spreads evenly across every inch of bread surface
  • Provolone cheese: Mild and melty with just enough tang to stand up to the cured meats
  • Salami: Provides that classic Italian sub flavor and gets beautifully crispy in the pan
  • Pepperoni: Adds a slight heat and more porky depth to every layer
  • Shredded iceberg lettuce: Stays crisp and cool creating that signature sub shop texture contrast
  • Mayonnaise and red wine vinegar: The secret duet that makes the lettuce topping taste exactly like your favorite deli
  • Dried oregano: One sprinkle transports the whole sandwich straight to Italy
  • Pepperoncini rings: Optional but highly recommended for that bright vinegar pop
  • Red onion: Adds a sharp fresh bite that cuts through all the richness

Instructions

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Make the lettuce topping:
Toss the shredded lettuce with mayonnaise red wine vinegar oregano salt and pepper until everything is evenly coated. Let it hang out while you prep everything else so the flavors can mingle.
Butter your bread:
Spread softened butter generously on one side of each bread slice. Do not skip this step or skimp because that butter is what creates the golden crispy magic.
Layer the foundation:
Place two slices buttered side down and pile on provolone salami and pepperoni. This is the hearty core of your sandwich so do not be shy with the layers.
Add the extras:
Scatter pepperoncini and red onion on top if you are using them. They tuck beautifully into the meat and cheese layers.
Spoon on lettuce:
Spread that tangy lettuce mixture right over the meats. It might feel strange to put lettuce inside a grilled cheese but trust the process.
Close it up:
Top each sandwich with the remaining bread slices buttered side up. Press down gently to help everything settle into place.
Get your sizzle on:
Cook in a hot skillet for about four minutes per side pressing gently with your spatula. Watch for that deep golden color and listen for the cheese to start melting.
Serve immediately:
Slice each sandwich diagonally and serve while the cheese is still molten. These do not reheat well so eat them hot and glorious.
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Effortlessly chop vegetables, slice meats, and prep ingredients smoothly for everyday cooking and recipe preparation.
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Close-up of a warm Italian Sub Grilled Cheese cut in half, revealing a melty cheese and savory cold cut filling. Save
Close-up of a warm Italian Sub Grilled Cheese cut in half, revealing a melty cheese and savory cold cut filling. | ladledrift.com

My dad tried one and immediately asked why I had never made these for family dinner before. Now he requests them every time he visits claiming they are better than the sandwich place he has been going to for thirty years. I think he might be right.

Bread Choices That Work

I have tested this with sourdough whole wheat and even ciabatta in a pinch. Italian bread with a sturdy crumb remains my favorite but any bread that can handle weight without crumbling will do the job beautifully.

Make It Your Way

Sometimes I swap in mozzarella for a milder flavor or add banana peppers if we are out of pepperoncini. The core formula stays the same even when the ingredients shift based on what is in the fridge.

Serving Suggestions

A handful of kettle chips on the side feels like the most natural pairing in the world. Or go for a simple tomato salad with olive oil and salt to cut through all that richness.

  • Cold Italian soda or beer makes the perfect beverage companion
  • Napkins are non negotiable these get gloriously messy
  • Cook them one at a time if you want them all equally perfect
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Two crispy Italian Sub Grilled Cheese sandwiches served on a wooden board with a side of tangy lettuce topping. Save
Two crispy Italian Sub Grilled Cheese sandwiches served on a wooden board with a side of tangy lettuce topping. | ladledrift.com

There is something deeply satisfying about taking familiar flavors and giving them a warm buttery twist. Now go make your kitchen smell amazing.

Recipe FAQs

What type of bread works best for this sandwich?

Italian bread or sturdy white sandwich bread provides the ideal foundation. For variations, try whole wheat or sourdough, which offer different textures and flavors while maintaining structural integrity during grilling.

Can I prepare the lettuce mixture in advance?

Yes, you can mix the lettuce, mayo, vinegar, and oregano up to 2 hours ahead. Store in the refrigerator and add just before assembling to prevent the bread from becoming soggy.

How do I prevent the cheese from leaking out?

Keep the heat at medium and cook for 3-4 minutes per side. Pressing gently while cooking helps the cheese meld with the bread. Avoid high heat, which can cause the cheese to escape before the bread crisps.

What substitutions work for the cold cuts?

Capicola, mortadella, or ham are excellent alternatives. You can also use a combination of different Italian meats based on preference. Adjust quantities to match your desired flavor intensity.

Is this sandwich suitable for meal prep?

While best served immediately after grilling, you can assemble sandwiches without the lettuce mixture several hours ahead and refrigerate. Add the lettuce topping just before cooking for optimal freshness and texture.

What side dishes pair well with this sandwich?

Kettle chips, a simple tomato salad, or roasted vegetables complement the rich flavors nicely. A light coleslaw or fresh fruit also balance the savory, indulgent nature of the sandwich.

Italian Sub Grilled Cheese

A melty, savory sandwich combining Italian cold cuts, provolone, and tangy lettuce topping grilled to golden perfection.

Prep time
10 minutes
Cook time
10 minutes
Time needed
20 minutes
Created by Zoey Sullivan


Skill level Easy

Cuisine Italian-American

Makes 2 Portions

Diet info None specified

What You Need

Bread & Dairy

01 4 slices Italian bread or sturdy white sandwich bread
02 2 tablespoons unsalted butter, softened
03 4 slices provolone cheese

Meats

01 6 slices salami
02 6 slices pepperoni

Lettuce Topping

01 1 cup shredded iceberg lettuce
02 2 tablespoons mayonnaise
03 1 tablespoon red wine vinegar
04 1 teaspoon dried oregano
05 Salt and freshly ground black pepper to taste

Optional Additions

01 2 tablespoons mild pepperoncini rings, drained
02 2 tablespoons thinly sliced red onion

How-To

Step 01

Prepare Lettuce Mixture: In a mixing bowl, combine shredded iceberg lettuce, mayonnaise, red wine vinegar, dried oregano, salt, and black pepper. Mix thoroughly and set aside.

Step 02

Butter Bread Slices: Lay out all bread slices and spread one side of each with softened butter.

Step 03

Layer Base Sandwich: Place two slices of buttered bread on a work surface with buttered side down. Top each with 2 slices provolone cheese, 3 slices salami, and 3 slices pepperoni.

Step 04

Add Optional Toppings: If desired, distribute pepperoncini rings and red onion slices evenly over the meats and cheese.

Step 05

Apply Lettuce Mixture: Spread the prepared lettuce mixture evenly over the meats and cheese layer.

Step 06

Complete Sandwiches: Top each sandwich with the remaining bread slices, placing them buttered side up.

Step 07

Grill Sandwiches: Heat a large skillet or grill pan over medium heat. Place sandwiches in the pan and cook 3 to 4 minutes per side, pressing gently with a spatula, until bread is golden brown and cheese is fully melted.

Step 08

Serve: Remove from heat, slice each sandwich in half diagonally, and serve while hot.

Tools needed

  • Large skillet or grill pan
  • Spatula
  • Mixing bowl
  • Knife and cutting board

Allergy notice

Double-check your ingredients for allergens, and ask a healthcare expert if you’re not sure.
  • Contains wheat from bread
  • Contains milk from cheese and butter
  • Contains eggs in mayonnaise
  • Contains pork from salami and pepperoni
  • Check all product labels for potential trace allergens

Nutrition info (per portion)

This nutrition guide is for general info—always consult a medical pro for advice.
  • Calorie count: 540
  • Fat content: 34 grams
  • Carbohydrates: 35 grams
  • Proteins: 24 grams